If you have informative censoring such as when you analyse a blinded, independent, central review (BICR) of progression what can you do? Currently there doesn’t seem to be a consensus and more research is needed but there are a few approaches you can take The simplest approach is to impute a BICR event at the next visit for the LOPs (local only progressors - patients who only the investigators believe have progressed and they stop scanning and are censored in the BICR analysi

Medians exaggerated In an oncology trial, whenever you’ve looked at a Kaplan Meier curve of a blinded, independent, central review (BICR) of progression those curves will be exaggerated. More specifically, the median, as estimated by the BICR, will be longer than it should be and longer than it would have been had those same independent reviewers been assessing the patients at the centres. What’s more, the stronger the correlation, between the local(investigator) assessmen